Comedian Kathy Griffin performs a stand-up comedy show at the Palace of Fine Arts Theatre in San Francisco, delivering her trademark celebrity-focused and politically sharp material. The event is staged at the historic Palace of Fine Arts in the Marina District, a monumental 1915 Panama–Pacific Exposition structure that provides a scenic theatrical setting for live performance. Griffin’s appearances draw on her long career in television and stand-up and are notable for their outspoken, topical humor.